Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5). Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.
There are no clinical trials involving CEACAM5, however the following
two clinical trials involve CEA (keep or change?).
NCT02349724 -
Lung Cancer, Colorectal Cancer, Breast Cancer, Pancreatic Cancer
NCT03267173 -
Pancreatic Cancer
The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene CEACAM5.
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present. The last three rows describe
the position of potential epitopes, as well as phosphorylation and
glycosylation sites.